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Q I am a year-old male student. I have had pimples on my face since secondary school. Although I have seen a specialist at a hospital, my acne does not seem to have improved much. I have tried isotretinoin and almost all types of anti-acne antibiotics, such as minocycline and tetracycline, but they are not effective. Instead of improving my acne condition, these antibiotics cause gastric pain and I have no appetite.