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It is possible that in certain individuals, Accutane can cause a severe allergic reaction. Symptoms of this include hives, a swollen face, tongue, lips, or throat. When should I speak to a doctor about Accutane side effects? How do I prepare for my online appointment? Other conditions to make the doctor aware of are: A personal or family history of mental illness Intestinal disorders Heart disease High cholesterol Bone disorders Asthma An eating disorder Diabetes Liver disease Pregnancy.

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I have to thank students past and present for their inspiration, comments and suggestions over the years and I hope future students and practitioners will benefit from this. Thanks to staff at Wiley, to Neil Manley for creating the index, and to Wendy Mould, who copyedited the book. Finally, thanks to Alex for his understanding and patience. Pharmacology is the science of drugs and their effects on biological systems.

Drugs that either improve the blood supply to the myocardium, or reduce its metabolic demand for oxygen or both can be used to treat angina. These drugs include nitrates, potassium channel activators, β-blockers and calcium channel blockers. Myocardial infarction occurs when there is a prolonged reduction in oxygen supply to a region of myocardium, due to narrowing of the arteries combined with sudden formation of a thrombus and blockage of a coronary artery.

Plasma protein concentration also falls with age. This means that for extensively protein bound drugs there will be a greater concentration of free drug than expected. This could lead to increased incidence of side effects. This is the case with pethidine (an analgesic).