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Since then, oral isotretinoin has been studied as therapy for several types of cancer, such as chemoprophylaxis of squamous cell carcinoma of the skin and certain types of leukemia. Many physicians are wary of prescribing isotretinoin based on its teratogenic effects and the potential liability associated with its use. The goals of iPLEDGE are to ensure that women using isotretinoin do not become accutane generic safe and that women who are pregnant do not use isotretinoin. In addition to concerns regarding fetal abnormalities, there continues to be controversy over the possible role of isotretinoin in causing suicide and depression. This issue warrants heightened precautions by prescribers.

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This ingredient essentially works by slowing the synthesis of skin in the sebaceous glands the main structures that produce skin fat. Accordingly, it prevents hypersecretion of sebum and also prevents clogging of hair follicles, which are otherwise clogged when combined with keratinized cells of the epidermis. Acne is, in fact, clogged sebaceous glands.

Sebum provides a normal appearance and activity of the skin. It is produced by microscopic glands and is secreted through special ducts. When such a duct is blocked, sebum accumulates in the gland and causes inflammation. In addition, a clogged gland has optimal conditions for the development of microorganisms and, as a result, the process is exacerbated.

In general, the effectiveness of isotretinoin is due to the impact on all major links of the pathogenesis of acne. Isotretinoin binds to nuclear receptors, resulting in reduced differentiation of the sebaceous glands cells, which leads to a marked decrease in their size, as well as the number and activity. The use of this component leads to a significant reduction in the synthesis of sebum, as well as prevents the appearance of comedones, which indirectly reduces the activity of propionic bacteria.

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Isotretinoin cis-retinoic acid is a synthetic retinoid or vitamin A derivative. The retinoids are involved in the HOX signaling pathways that are used to pattern the branchial arches pharyngeal arches during the fourth week of embryonic development. Children with the isotretinoin syndrome often demonstrate facial asymmetry; serious external ear abnormalities, including microtia small ear, anotia no ear, or stenosis of the external ear canal; micrognathia small jaw ; flat depressed nasal bridge; and ocular hypertelorism widely spaced eyes.

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