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The acne drug Accutane is one of the most dangerous products on the market today. The drug causes serious side-effects, most notably birth defects. This combination—unique efficacy coupled with unique risk—has posed a serious challenge for the Food and Drug Administration FDA. Over the past two decades, FDA has grappled with how manage the completely preventable but persistently serious problem of Accutane-induced birth defects. On several occasions, the product spurred FDA to take unprecedented regulatory action. In when American researchers for Hoffmann-La Roche began studying the chemical, isotretinoin, they were struck by its remarkable effectiveness.

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Accutane inhibits the production of sebum and reduces the size of the gums with the main active substance isotretinoin. It is proved that isotretinoin has an antiseptic effect. Also, isotretinoin thinens the stratum corneum of the epidermis to more easily penetrate deep into the affected area. Due to the fact that Accutane suppresses the sebum secretion by reducing the sebaceous glands themselves, this allows to reduce the migration of bacteria in the ducts. And due to the fact that the stratum corneum is thin, the skin fat has an outlet to the outside, from which there is no blockage of the pores and, as a result, pimples.