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Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Acemetacin may decrease the excretion rate of Isoniazid which could result in a higher serum level. General Function Catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines PubMed As acetyl-CoA and propionyl-CoA are products of cholesterol catabolism and the nat gene is likely present in the same operon than genes involved in cholesterol degradation, this enzyme could have a role in the utilization and regulation of these CoA species PubMed General Function Steroid hydroxylase activity Specific Function Exhibits a high coumarin 7-hydroxylase activity.
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Authored by Richard Gayles, MD