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Simultaneously, research in obesity treatment has advanced, and leaders in the field have issued complementary guidance. Measurement of body mass index is recommended to initiate evaluation for overweight and obesity and determine disease classification. Although lifestyle therapy remains the cornerstone of treatment for this disease, both pharmacotherapy and metabolic and bariatric surgery produce greater and more sustained weight loss in treatment-approved populations as compared with lifestyle modifications alone. An ongoing partnership between the patient and clinician is highly recommended to manage this serious, progressive, chronic disease. It also highlights consensus that obesity is a serious, progressive, and chronic disease. Waist circumferences of at least cm approximately 40 in.