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Setmelanotide, sold as Imcivree, is in a class of medications known as melanocortin 4 MC4 receptor agonists. How it works: People with specific genetic mutations may experience insufficient activation of the MC4 receptor in the brain, which could contribute to obesity. Setmelanotide works by increasing the activation of this receptor, leading to reduced hunger, decreased calorie intake, and increased metabolism, all of which could promote weight loss.
Contraindications: This medication is not recommended for people with renal impairment, and those who are pregnant or breastfeeding. There are several anorectics, or appetite suppressants, available. How it works: These medications reduce appetite by altering levels of certain neurotransmitters in the brain, which can lead to weight loss. However, keep in mind that these medications are only recommended for short-term use, as you can build up a tolerance after several weeks, resulting in decreased effectiveness.
Side effects: Potential side effects may include nausea, vomiting, diarrhea, and stomach cramps. However, research on the effectiveness and safety of these products is limited. There are also several dietary supplements, including herbs and stimulants, that have been suggested to be helpful for weight loss. Studies also suggest that people with higher body weights are disproportionately more likely to experience disordered eating and eating disorder symptoms.
These behaviors may indicate a disordered relationship with food or an ED. Disordered eating and EDs can affect anyone, regardless of gender identity, race, age, body size, socioeconomic status, or other identities. They can be caused by any combination of biological, social, cultural, and environmental factors — not just by exposure to diet culture. GLP-1 agonists are currently the most effective antiobesity medications and are considered safe for long-term use.
Currently, only liraglutide Saxenda and semaglutide Wegovy are approved for weight loss, though some other GLP-1 drugs may be prescribed off-label. Still, keep in mind that individual results can vary based on many factors, including your diet, health status, and activity level. In addition to maximizing your potential results, it can increase the likelihood of maintaining weight loss in the long term. Some manufacturers also offer savings cards, which can help lower the cost of your copay.
Additionally, though they can promote weight loss and may even offer other health benefits, note that these medications are not suitable for everyone and can lead to weight regain once you stop taking them. A doctor or other trusted healthcare professional can help you determine which is right for you and how to incorporate it into a healthy weight management plan.
Obesity is a chronic condition, and medications are just one part of a treatment plan to help achieve and maintain weight loss. Instead, they should be used only as directed and paired with a balanced diet, healthy lifestyle, and regular physical activity for best results. This article tells you all you need to know about GLP-1 agonists like Wegovy, including whether they are safe and effective for weight loss.
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Authored by Dr. Nancy Jane Hamilton, DDS