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Increased propensity for calcium phosphate kidney stones with topiramate use. Acute topiramate overdose--clinical manifestations. Monitoring Renal impairment: Clinicians need to consider the glomerular filtration rate GFR for patients with renal impairment. It is recommended to take this medication in the morning to prevent insomnia. Enhancing Healthcare Team Outcomes Obesity is a global issue, and almost every country faces this serious public health problem.

It is a central nervous system stimulant. This can lead to high body temperature, agitation, sweating, tremors, dilated pupils, hyperreflexia, and diarrhea. Pharmacotherapy for Obesity. Topiramate was discovered in but was not released for commercial use until Topiramate on its own has been used to treat partial-onset or primary generalized tonic-clonic seizures, Lennox-Gastaut syndrome, and as a prophylactic treatment of migraine headaches. Renal impairment: Clinicians need to consider the glomerular filtration rate GFR for patients with renal impairment.

Disclosure: Judy Quick declares no relevant financial relationships with ineligible companies. Topiramate is a weak carbonic anhydrase inhibitor; therefore, it can lead to metabolic acidosis, hypokalemia and may lead to the development of nephrolithiasis. In the cases of severe acute overdose, medical toxicologist consultation is required. Constipation is also a real issue with this drug combination, and the patient should be told to increase fiber in the diet, drink more water, and use stool softeners or laxatives as needed.

An interprofessional approach is necessary to maximize efficacy and minimize adverse drug reactions, enhancing patient outcomes. Reevaluate again in 12 weeks. Endocrinol Metab Clin North Am. Similar articles in PubMed. Hemodialysis is an phentermine oral buy means of removing topiramate from the body. Any patient with a history of the cardiac or cerebrovascular disease should use caution. Topiramate in Migraine Prevention: A Perspective. In addition, the critical care physician consultation is necessary if the patient requires MICU level of care requiring intubation and mechanical ventilation.

Topiramate is also a weak carbonic anhydrase inhibitor, and it also antagonizes glutamate receptors. A Child-Pugh score of 5 or 6 indicates that no adjustment needs to be made. Acute myopia associated with secondary angle-closure glaucoma may occur with use. Topiramate augments appetite suppression and satiety enhancement based on the combination of the mechanisms above.

Continue on the lowest dose for 14 days, then increase to the 7. Clinical dieticians should prescribe individual diet plans for the patient and educate the patient that a change in diet is necessary for any intervention to work. Avoid combination with anticholinergics which can increase the risk of hyperthermia.

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Commercial: 30 mg Capsule Commercial: Limited data are available in reference texts regarding the mechanism of action of this drug. The elimination half-life ranges 19—24 hours and is influenced by urinary pH. Renal Impairment: Use with caution in patients with renal impairment. Therefore, coadministration of these drug products for weight loss is not recommended.

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