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Acxion has the potential to cause a number of side effects. My doctor said I need to lose at least 50 pounds. Topiramate has been rarely associated with hepatic injury and largely when used in combination with other anticonvulsant medications. However, rare side effects such as severe heart, lung or mental problems can occur. Tell your doctor right away if you have trouble breathing, chest pain, swelling in your legs or a lowered ability in.