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Obesity presents a growing challenge in the United States, particularly in childhood and adolescence. Adolescents often encounter mental health challenges such as anxiety and depression due to their stage of development. To help address this crisis, medication-based therapies have emerged over the past two decades designed to promote weight loss. In an effort to address questions about the cost-effectiveness of popular weight loss medications, investigators from Columbia University and the University of Minnesota conducted an analysis using computer modeling to determine which of the prominent anti-obesity drugs indicated for adolescents offered the most cost-effective weight loss treatment. The model simulated patient outcomes and costs for each treatment option, allowing for direct cost and benefit analysis between the different therapeutic choices for obesity in adolescents through quality-adjusted life years QALYs, a standardized method for assessing improvements in overall health or quality of life.

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