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Alcohol, sometimes referred to by the chemical name ethanol, is a depressant drug that is the active ingredient in drinks such as beer, wine, and distilled spirits hard liquor. Ethanol is only one of several types of alcohol ; other alcohols such as methanol and isopropyl alcohol are significantly more toxic. Unlike primary alcohols like ethanol, tertiary alcohols cannot be oxidized into aldehyde or carboxylic acid metabolites, which are often toxic. For example, the tertiary alcohol 2M2B is 20 times more potent than ethanol, and has been used recreationally. Alcohol has a variety of short-term and long-term adverse effects. Short-term adverse effects include generalized impairment of neurocognitive function, dizziness, nausea, vomiting, and hangover-like symptoms. Alcohol is addictive to humans, and can result in alcohol use disorder, dependence and withdrawal.

To date, three medications—disulfiram Antabuse, naltrexone Trexan, and acamprosate Campral —have been approved by the U. Food and Drug Administration FDA for the disulfiram tablet cost of alcohol dependence, and only about 20 percent of eligible patients receive them. Naltrexone is an opioidreceptor antagonist approved for use in the treatment of alcohol dependence in conjunction with psychosocial interventions. Short-term outcomes in favor of naltrexone included fewer patients relapsing to alcohol dependence 38 versus 60 percent with placebo, fewer patients returning to drinking 61 versus 69 percent, reduced cravings for alcohol, and fewer drinking days. The recommended dosage of naltrexone is 50 mg per day in a single dose. Long-term opioid therapy for chronic pain or heroin dependence is a contraindication for naltrexone because the drug could precipitate severe withdrawal syndrome.

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