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Shirin Ghanavatian ; Armen Derian. Authors Shirin Ghanavatian 1 ; Armen Derian 2. Baclofen is used to treat order lioresal generic spasticity; it is FDA-approved for managing reversible spasticity, particularly for the relief of flexor spasms, clonus, and concomitant pain, common sequelae of spinal cord lesions, and multiple sclerosis. Baclofen also has several off-label uses. This activity outlines the indications, mechanism of action, safe administration, adverse effects, contraindications, toxicology, and monitoring of the broad array of physiological possibilities when using baclofen in the clinical setting. Objectives: Identify the approved and off-label indications for baclofen.

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