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Baclofen has become increasingly popular in the treatment of spasticity disorders. Its availability for misuse has also increased. If a past medication history is not immediately available, baclofen overdose should be included in the differential diagnosis of an acutely confused patient complicated with rhabdomyolysis, as routine toxicology screening does not include baclofen. Baclofen is commonly used to treat spasticity. We describe a patient with baclofen overdose presenting to the emergency department ED with atypical symptoms of acute delirium and rhabdomyolysis. A year-old man was found lying unconscious on the floor in his apartment and was brought to the emergency department by ambulance.

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Treatment of spastic conditions occurring in spinal-cord diseases of infectious, degenerative, traumatic, neoplastic, or unknown origin: e. Baclofen Lioresal is also indicated for the symptomatic treatment of muscle spasms occurring in spinal cord diseases of infectious, degenerative, traumatic, neoplastic, or unknown origin such as multiple sclerosis, spastic spinal paralysis, amyotrophic lateral sclerosis, syringomyelia, transverse myelitis, traumatic paraplegia or paraparesis, and compression of the spinal cord. Contraindications: Known hypersensitivity to baclofen or to any of the excipients. Adequate anticonvulsive therapy should be continued and the patient should be carefully monitored. Others: Baclofen Lioresal should be used with caution in patients with, or with a history of, peptic ulcers, as well as in patients with cerebrovascular diseases or with respiratory or hepatic impairment. Particular caution is required when combining with drugs or medicinal products which may significantly impact renal function. Renal function should be closely monitored and baclofen Lioresal daily dosage adjusted accordingly to prevent toxicity. Besides discontinuing treatment, unscheduled hemodialysis might be considered as a treatment alternative in patients with severe baclofen toxicity.

Baclofen is classified under centrally acting muscle relaxants. This class of drugs bring about the reduction in tone of skeletal muscles and relaxation of these muscles. This action of Baclofen proves advantageous in conditions where muscle spasticity is a prominent feature. These include acute spasms such as those seen in sprains, muscle pulls overstretching, ligament and tendon tears; and chronic conditions, for e. How Baclofen Works: Baclofen is a centrally acting muscle relaxant agent.

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Baclofen use may occasionally be advised in pregnancy if it is needed to control severe muscle spasms. Baclofen use may be advised to control pain and improve problems with mobility and day-to-day function that are caused by severe muscle spasms. In these cases, the benefits to both woman and baby of ensuring the woman remains well are likely to outweigh any baclofen 10 mg tablet online risks. Baclofen use in pregnancy has been studied in only around women. Baclofen taken by mouth can potentially cause short-term withdrawal symptoms in the newborn baby if taken in the weeks before delivery. For this reason, a baby may be monitored for some time after birth to check for symptoms such as jitteriness, difficulty sleeping and breathing problems.

Lioresal, or as its marketed as Baclofen, is known as an agonist of the gamma-aminobutyric acid type B receptor 1 and first synthesised in the s 2. It became an FDA-approved drug in 3. Originally approved for the treatment of spasticity in neurological conditions and spinal cord lesions, Baclofen has recently been used for the treatment of alcohol dependence 4;5. In addition, Baclofen is known to have muscle-relaxant properties 4. It is often administered to relieve flexor spasms, which are known as involuntary muscle contractions which are notable with patients suffering from spinal cord issues 8.

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The Ministry of Public Health. International Health Regulations. Epidemiological Surveillance. National Tuberculosis Program. No Tobacco Control Program. Lebanon National Drugs Database.