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These patients are described as intolerant. They exhibit the expected response to the drug but in a greater magnitude than would be acceptable.
Tuberculosis infection is difficult to treat and requires a combination of at least three different antibiotics. Viral infections are normally overcome by the patients immune system.
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It should be used with caution in combination with allopurinol because allopurinol inhibits xanthine oxidase. Both methotrexate and mercaptopurine are used to treat acute leukaemia. Fluorouracil is a pyrimidine analogue that substitutes for uracil in the synthesis pathway for thymidylate, a necessary step in the synthesis of DNA.
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Authored by Dr. Javier P Berrios, MD