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Blood pressure was measured by ABPM every 15 to 30 minutes for up to 36 hours after tadalafil or placebo. During the hour period after 8 p. Some additional subjects in both the tadalafil and placebo groups were categorized as outliers in the period beyond 24 hours. After 7 days, doxazosin was initiated at 1 mg and titrated up to 4 mg daily over the last 21 days of each period 7 days on 1 mg; 7 days of 2 mg; 7 days of 4 mg doxazosin.

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Blood pressure was measured manually at 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, and 24 hours after tadalafil or placebo dosing. Daily dosing of tamsulosin 0. Blood pressure was measured manually pre-dose at two time points and minutes and then at 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, and 24 hours post dose on the first, sixth and seventh days of tamsulosin administration. Blood pressure was measured manually at 1, 2, 3, 4, 6, 8, 10, 20, and 24 hours after tadalafil or placebo dosing.

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