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Introduction: Premature ejaculation PE is a common male sexual disorder. An ideal, reliable and effective treatment is desired by many men and couples affected by this condition. Aim: Evaluate if the association of a phosphodiesterase-5 inhibitor, tadalafil, and a selective serotonin reuptake inhibitor, fluoxetine, can prolong the intravaginal ejaculatory latency time IELT in men with lifelong premature ejaculation. Methods: Sixty patients with lifelong premature ejaculation and without erectile dysfunction ED with IELT less than 90 s were enrolled in the protocol and randomized into 4 groups to use a combination of medications: 1 tadalafil 20 mg plus fluoxetine 90 mg, 2 fluoxetine 90 mg plus placebo, 3 tadalafil 20 mg plus placebo, and 4 two different placebo capsules control. Before starting the medications, each man timed paypal tadalafil IELT with a stopwatch, and likewise during the treatment period.
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