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This trial was designed to investigate the potential effectiveness of a single dose of methotrexate, 75 mg intramuscularly, in a regimen for early abortion. The misoprostol dose was repeated if the abortion did not occur.
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Mifepristone blocks the effects of progesterone, a natural female hormone that is needed for the pregnancy to sustain. Without this hormone, the lining of the uterus womb breaks down as it does during a menstrual period and stops the growth of the pregnancy. Misoprostol increases contractions of the uterus to cause abortion. Unwanted Mankind Pharma Ltd. Gestapro Biochem Pharmaceutical Industries. Mifty Aristo Pharmaceuticals Pvt Ltd.