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Fluconazole is a triazole antifungal drug wherein sensitive fungi inhibits cytochrome Pdependent enzymes, resulting in impairment of ergosterol synthesis in fungal cell membranes. Salivary concentrations of fluconazole after oral doses should be adequate for the treatment of orophayrngeal and esophageal candidiasis even in patients with AIDS who may have decreased salivation. Treatment failures are more likely due to inadequate dosage or resistant organisms than to decreased salivary secretion. It is also given for systemic infections including systemic candidiasis, coccidioidomycosis and cryptococcosis, and has been tried in blastomycosis, histoplasmosis and sporotrichosis. For superficial mucosal candidiasis: usual dose is 50 mg daily, mg daily may be given if necessary. Treatment usually continues 7 to 14 days in oropharyngeal candidiasis except in severely immunocompromised patients, for 14 days in atrophic oral candidiasis associated with dentures, and for 14 to 30 days in other mucosal candida infections including esophagitis.
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