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Background Doxycycline has a high degree of activity against many common cheap doxycycline pathogens and has been used in the outpatient management of lower respiratory tract infections, including pneumonia. Objective To evaluate the efficacy of intravenous doxycycline as empirical treatment in hospitalized patients with mild to moderately severe community-acquired pneumonia. Patients and Methods We conducted a randomized prospective trial to compare the efficacy of intravenous doxycycline with other routinely used antibiotic regimens in 87 patients admitted with the diagnosis of community-acquired pneumonia. Forty-three patients were randomized to receive mg of doxycycline intravenously every 12 hours while 44 patients received other antibiotic s control group. The 2 patient groups were comparable in their clinical and laboratory profiles. Doxycycline was as efficacious as the other regimens chosen for the treatment of community-acquired pneumonia. Conclusion Doxycycline is an effective and inexpensive therapy for the empirical treatment of hospitalized patients with mild to moderately severe community-acquired pneumonia. However, a definitive cause is not usually established; and if there is a good clinical response, the course of therapy is completed with the initially chosen antibiotic. Combinations of antibiotics are often used and these regimens can be expensive.
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