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Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne. Given the role of host inflammatory response in acne, the researchers tested sub-antimicrobial dosing of doxycycline in adults with moderate acne. Patients were assessed at baseline and at 2, 4, and 6 months. Secondary outcomes included the clinician global assessment and the patient self-assessment scores using a 7-point qualitative scale. Forehead skin flora samples were collected at baseline and at 6 months to assess for changes in microflora or resistance patterns. The authors propose that doxycycline 20 mg generic acne may be treated with doxycycline in subantimicrobial doses mg tablets taken twice daily. This regimen was well-tolerated, moderately effective in reducing skin lesions, and did not have a detectable effect on the antibiotic resistance of skin flora. Low-dose doxycycline moderately effective for acne.
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