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Insomnia Starting: 1 mg at bedtime Maintenance: 1 - 3 mg at bedtime Elderly patients: do not exceed 2 mg When taken with CYP3A4 strong inhibitors, do not exceed 2 mg High-fat meals slow absorption and may decrease effect. Kidney disease No dose adjustment is necessary. Eszopiclone is a CIV controlled substance Abuse and dependence may occur in susceptible patients. Peak concentration: 1 hour Half-life: 6 hours. CYP3A4 inhibitors and inducers may affect eszopiclone levels.

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