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Please verify that you are a US Healthcare Professional. Are you a US Healthcare Professional? Learn about reducing the risk of further worsening of your kidney disease and end-stage kidney disease. Learn about the connection between type 2 diabetes or high blood pressure and CKD and how you can find out if you have CKD. Learn about improving blood sugar while reducing the risk of heart failure hospitalization in those with heart disease or risks for it. Learn about reducing your risk of hospitalization for heart failure.


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Tirzepatide Mounjaro is labeled for the treatment of type 2 diabetes mellitus in adults as an adjunct to lifestyle modifications. It is the first agonist that targets both glucagon-like peptide-1 GLP-1 and glucose-dependent insulinotropic polypeptide receptors. Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma and in patients with multiple endocrine neoplasia syndrome type 2. Rarely, acute pancreatitis has been associated with the use of tirzepatide and other GLP-1 receptor agonists. Tirzepatide delays gastric emptying, which may reduce the effectiveness of oral contraceptives. If switching to a non—oral contraceptive method is not preferred by the patient, a barrier method is recommended for four weeks after initiation and dose escalation.

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