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Glucophage SR may be used as monotherapy or in combination with other oral antidiabetic agents, or with insulin. A slow increase of dose may improve gastro-intestinal tolerability. The maximum recommended dose is 4 tablets mg once daily with the evening meal. Monotherapy in Type 2 diabetes mellitus and combination with other oral antidiabetic agents The maximum recommended dose is 4 tablets daily.

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The first patient was enrolled on September 10, and the last patient concluded the study on May 4, Patients were excluded if they had a history of ketoacidosis or had unstable or rapidly progressive diabetic retinopathy, nephropathy, or neuropathy; impaired hepatic or renal function; or severe anemia. Patients with serious cardiovascular disease CVD or cerebrovascular conditions within 6 months before study enrollment were also excluded. Women who were pregnant or breastfeeding or of childbearing potential and not taking adequate contraceptive precautions were also excluded. Before starting the study, all patients underwent an initial screening assessment that included a medical history, physical examination, vital signs, and a lead electrocardiogram.