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Because of the anti-inflammatory effects they are known as non-steroidal anti-inflammatory drugs, or NSAIDs ( Figure NSAIDs exert their effects by inhibition of the enzyme cyclo-oxygenase. This results in reduced production of prostaglandins and thromboxanes because COX normally catalyses their formation from arachidonic acid.
Thus, the number of functioning hepatocytes is reduced, and therefore so is the capacity to metabolize drugs. The process known as first pass metabolism is drastically reduced with ageing.
Authored by Dr. Cory Alfers, DO