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Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase -4 DPP-4 enzyme. Sitagliptin phosphate monohydrate is a white to off-white, crystalline, non-hygroscopic powder. The sitagliptin layer is coated with a soluble polymeric film. Initial combination therapy or maintenance of combination therapy should be individualized and left to the discretion of the healthcare provider. The tablets must not be split, crushed, or chewed before swallowing. It is not known whether this material seen in feces contains active drug.

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There are four patents protecting this drug and one Paragraph IV challenge. This drug has one hundred and thirty-six patent family members in forty-six countries. There are forty-nine drug master file entries for this compound. Two suppliers are listed for this compound. Janumet was eligible for patent challenges on October 16, By analyzing the patents and regulatory protections it appears that the earliest date for generic entry will be May 24, This may change due to patent challenges or generic licensing. There have been twenty-seven patent litigation cases involving the patents protecting this drug, indicating strong interest in generic launch. Many factors can influence early or later generic entry.

The medicine is taken twice a day and the dose depends on the dose of the sitagliptin metformin generic diabetes medicines that the patient was taking before. Type 2 diabetes is a disease in which the pancreas does not make enough insulin to control the level of glucose in the blood or where the body is unable to use insulin effectively. Sitagliptin is a dipeptidyl-peptidase-4 DPP-4 inhibitor. It works by blocking the breakdown of incretin hormones in the body which are released after a meal and stimulate the pancreas to produce insulin. By increasing levels of incretin hormones in the blood, sitagliptin stimulates the pancreas to produce more insulin when blood glucose levels are high.

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Lactic acidosis is a medical emergency that must be treated in a hospital. Pancreatitis may be severe and lead to death. Certain medical problems make you more likely to get pancreatitis. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication. Patents are granted by the U. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

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We always guarantee you the lowest price! Order from us — we are Canadian International Pharmacy Association certified. Together, these medications work to lower blood sugar in multiple ways Nine of 10 people with diabetes have this type. In a healthy body, insulin helps sugar make its way into the body's cells, where it can be used for energy.

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Sitagliptin works by regulating the levels of insulin your body produces after eating. This medicine is not for treating type 1 diabetes. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk. Be sure your caregivers know ahead of time that you are using this medication.

The study design was open-label, single-dose, randomized with two-way crossover periods. Safety evaluations included vital signs, clinical laboratory tests, and adverse events AEs. All AEs were nonserious, transient, and mostly mild. Therefore, the new products are expected to provide efficacy and tolerability sitagliptin metformin generic to those of the reference products in the treatment of patients with type 2 diabetes T2D. Therefore, the new generic products are expected to provide similar clinical benefits for patients with type 2 diabetes to the approved reference products. The aim of such treatments is to provide patients with T2D with effective therapy, tailored to their individual needs.