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Sildenafil is a phosphodiesterase inhibitor used for the treatment of erectile dysfunction. In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate cGMP by inhibiting cGMP specific phosphodiesterase type 5 PDE5 11, 12, 13, 14, 15, 16, 8, 9. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid 11, 12, 13, 14, 15, 16, 8, 9. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart - before being serendipitously indicated for treating erectile dysfunction in the late s 7. Sildenafil is a phosphodiesterase-5 PDE5 inhibitor that is predominantly employed for two primary indications

Light yellow, capsule shaped, approximately 11 mm in length and 5. In order for tadalafil to be effective for the treatment of erectile dysfunction, sexual stimulation is required. In general, the recommended dose is 10 mg taken prior to anticipated sexual activity and with or without food. In those patients in whom tadalafil 10 mg does not produce an adequate effect, 20 mg might be tried. It may be taken at least 30 minutes prior to sexual activity. Tadalafil 10 mg and 20 mg is intended for use prior to anticipated sexual activity and it is not recommended for continuous daily use.

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