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The mean half-life of unconjugated lorazepam in human plasma is» 12 hr and for its major metabolite, lorazepam glucoronide,» 18 hr. Treatment of status epilepticus; relief of chemotherapy-induced nausea and vomiting; acute alcohol withdrawal; psychogenic catatonia. Contraindications Psychoses; acute narrow-angle glaucoma; intra-arterial administration injection ; hypersensitivity to benzodiazepines. IV Initial dose: 2 mg total or 0.
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It is treated as an emergency with dantrolene, which causes muscle relaxation. Nitrous oxide has a low potency and must be used in combination with other inhalation anaesthetics for general anaesthesia. Nitrous oxide provides rapid induction and recovery.
However, corticosteroids remain useful for small lesions. Combining corticosteroids with other topical treatment is effective in some cases. These drugs are reserved for patients with the most severe forms of psoriasis that do not respond to, or cannot tolerate, topical or phototherapy.
Antimuscarinic drugs are used as premedication to prevent salivation and bronchial secretions during an operation and to protect the heart from arrhythmias caused by inhalation anaesthetics such as halothane and propofol. They are less commonly used nowadays because modern anaesthetics are less irritant. Hyoscine is antiemetic, sedative and produces some amnesia.
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Modern diagnostic classifications depend on the presence or absence of positive or negative symptoms as well as the duration of symptoms according to either the ICD- Negative symptoms are social withdrawal, lack of emotional responsiveness and apathy; positive symptoms are hallucinations, thought disturbances, delusions, restlessness and aggression. Some psychoses can be secondary to other diseases such as infection and peripheral vascular disease or intoxication with drugs or alcohol, but most often the aetiology is unknown.
Authored by Seth M. Weinreb, MD, FACS