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Agitation Alcohol withdrawal symptoms Muscle spasms Sedation Restless legs syndrome Sleepwalking disorder. Benzodiazepines act through the gamma-aminobutyric acid GABA A receptor, which regulates chloride entry into neurons, resulting in neuronal hyperpolarization 1. The dosage of a benzodiazepine will vary depending on the patient and his or her history of sedative use. Although similar in many ways, the choice of an agent is often based on its pharmacokinetic properties, especially onset of action, half-life, and metabolic pathway. Oral dose equivalences of benzodiazepines 2: Agent. Elderly patients often require lower benzodiazepine doses due to slower metabolism of the drugs. When possible, avoid use during the first trimester Minimize use; i.

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