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Tamoxifen may be used as detailed below, although these situations are considered outside the scope of its licence Treatment of infertility contra-indicated if personal or family history of idiopathic venous thromboembolism or genetic predisposition to thromboembolism. Alopecia; anaemia; cataract; cerebral ischaemia; constipation; diarrhoea; dizziness; embolism and thrombosis; fatigue; fluid retention; headache; hepatic disorders; hot flush; hypersensitivity; hypertriglyceridaemia; muscle complaints; nausea; neoplasms; retinopathy; sensation abnormal; skin reactions; taste altered; uterine disorders; vaginal haemorrhage; vomiting; vulvovaginal disorders. Hypercalcaemia; interstitial pneumonitis; leucopenia; pancreatitis; thrombocytopenia; vision disorders. Tamoxifen can increase the risk of thromboembolism particularly during and immediately after major surgery or periods of immobility consider interrupting treatment and initiating anticoagulant measures. Unless being used in the treatment of female infertility, effective contraception must be used during treatment and for 2 months after stopping.
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UK prices for generic cancer drugs have risen sharply in the past five years, restricting their use in treating NHS patients, research from the European Cancer Congress has tamoxifen pill price. Drugs such as tamoxifen and bulsufan are now 10 times more expensive despite no longer being under patent. The British Generic Manufacturers Association said trusts often paid much less than the list price. The Department for Health said it has plans to cut generic drug costs. Drugs start off being on-patent, and their high prices allow pharmaceutical companies to profit from their investments in research and development. However, because of high drug prices, the NHS is often not able to approve some new cancer drugs for use.
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