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What is olanzapine, and how does it work mechanism of action? Olanzapine is a drug that is used to treat schizophrenia and acute manic episodes associated with bipolar I disorder. Other members of this class include clozapine Clozaril, risperidone Risperdal, aripiprazole Abilify and ziprasidone Geodon. The exact mechanism of action of olanzapine is not known. It may work zyprexa zydis olanzapine 5mg blocking receptors for several neurotransmitters chemicals that nerves use to communicate with each other in the brain. It binds to alpha-1, dopamine, histamine H-1, muscarinic, and serotonin type 2 5-HT2 receptors.

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