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Contrast agents are substances that alter, or attenuate, X-rays. The density of a substance determines the degree of attenuation of radiation. Air and gas can be used as contrast agents. They provide negative contrast because they absorb X-rays less than the surrounding tissue. They appear darker on X-ray film and are used to show the outline of surrounding soft tissue.
For severe eczema refractory to other treatment, ciclosporin is licensed for oral use and tacrolimus is licensed for topical use. Adverse effects of cyclosporin are toxicity to bone marrow, nausea, leukopenia, blurred vision and rashes. Adverse effects of topical application of tacrolimus are rash, irritation, pain and paraesthesia. Psoriasis is a chronic inflammatory skin disease affecting about The condition is characterized by hyperproliferation of keratinocytes. Cell turnover in the epidermis is increased with cells reaching the surface in as few as normal containing nuclei piling up on the surface.
Osteoporosis may also occur due to hormone imbalances or chronic hormone therapy. Bone mass begins to decline naturally after the age of vertebral collapse. Specialized radiographic imaging techniques or bone biopsy are used to diagnose and monitor the condition. Where the condition occurs in the young it is secondary to another cause, for example osteogenesis imperfecta, Cushings disease, Crohns disease or prolonged immobility. Osteoporosis can be prevented or reduced by regular exercise and adequate dietary intake of calcium and vitamin D throughout life but especially in adolescence.
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A form particularly difficult to treat is palmoplantar psoriasis on the hands and feet. Pustular and erythrodermic psoriasis are two rare forms of the disease, which present as medical emergencies.
Mebendazole has few side effects; it may cause mild gastrointestinal disturbances. Piperazine is effective against round worms and threadworms.
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Infected cells form granulomas enclosing the organism and replacing healthy tissue. In the centre of a granuloma is an area of necrotic tissue, referred to as caseation, which can become fibrotic and calcified. The granulomas contain bacteria lying dormant but capable of becoming reactivated later in the patients life if they become ill from some other cause or become immunosuppressed. Treatment for tuberculosis is lengthy taking up to two years and requiring combinations of at least three different antibiotics.
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Authored by Dr. Gregory Obara, MD