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Galantamine 4, a naturally occurring plant tertiary alkaloid, is a reversible AChE inhibitor that is a weak positive allosteric modular of nAChRs. The proposed presynaptic actions of galantamine buy dostinex australia also lead to the modulation of glutamate, serotonin, and norepinephrine release, all of which are affected in AD. Unlike rivastigmine, galantamine is metabolized by cytochrome P enzymes, CYP2D6 and CYP3A4, with doses of this drug being lowered if it is co-administered with other drugs that inhibit these enzymes. It is a reversible competitive inhibitor of acetylcholinesterase. Uses Galantamine has been used for many years to treat a range of neurological diseases, but is currently used in the treatment of various dementias. It has been used to treat Alzheimer's disease, vascular dementia, Parkinson's disease with dementia, Lewy body dementia, and patients with dementias due to combinations of causes.
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