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Please save your reference number: for further communication. How the modulation of dopamine and noradrenaline treat MDD and SAD is not well understood by clinicians and researchers. MDD is a complex disease with many causative factors and symptoms.

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Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. When used as an aid to smoking cessation, bupropion is thought to confer its anti-craving and anti-withdrawal effects by inhibiting dopamine reuptake, which is thought to be involved in the reward pathways associated with nicotine, and through the antagonism of the nicotinic acetylcholinergic receptor. Bupropion is sometimes used as an add-on agent to first-line treatments of depression such as selective serotonin reuptake inhibitor SSRI medications when there is a treatment-failure or only partial response. This includes the hypothalamus, which is involved in appetite regulation, and the mesolimbic dopamine circuit, which is involved in reward pathways.

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Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Bupropion acts as a norepinephrine—dopamine reuptake inhibitor and a nicotinic receptor antagonist. Bupropion was invented by Nariman Mehta, who worked at Burroughs Wellcome, in Bupropion has several features that distinguish it from other antidepressants: for instance, unlike the majority of antidepressants, it does not usually cause sexual dysfunction, and the occurrence of sexual side effects is not different from placebo.

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For 60 years, oral antidepressants have all been thought to work in generally the same way. Until Auvelity — an oral treatment for adults buy wellbutrin major depressive disorder MDD. While the exact way Auvelity works to treat depression is unclear, it affects certain brain chemicals thought to be involved in depression.

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