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Monitoring multiple myeloma patients treated with daratumumab: teasing out monoclonal antibody interference. Data for the end of induction, end of ASCT, and end of consolidation are from the primary analysis. Daniela Hoehn, Daniela Hoehn. The supplemental Appendix includes details regarding pre- and postinfusion medications and dose modifications. Starting at cycle 7, all patients received maintenance therapy day cycles consisting of oral lenalidomide 10 mg daily on days ; increasing to 15 mg after 3 cycles, if tolerated.

Achievement of MRD negativity has also been associated with superior long-term patient outcomes, resulting in increasing interest in this end point as a surrogate marker for PFS and OS. The results from GRIFFIN confirm previous findings that the addition of daratumumab to standard-of-care regimens across lines of therapy improves MRD negativity in myeloma,25,27 which has consistently translated into improved PFS, whether the backbone regimen was used for a defined duration 21,22,26,27 or until disease progression.

Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma. Primary analysis: summary of responses by the end of consolidation. Demographics and clinical characteristics were well balanced between randomized groups Table 1. Daratumumab in combination with lenalidomide plus dexamethasone induces clonality increase and T-cell expansion: results from a phase 3 randomized study POLLUX abstract. Kaufman, Jacob Laubach, Douglas W.

Blood ; 8: — Median times to neutrophil and platelet engraftment were comparable. Median age was 60 years range, years ; median time since diagnosis was 0. The most common reasons for discontinuation were investigator-assessed progressive disease PD; D-RVd, 6. The secondary end point of the MRD-negativity rate was defined as the proportion of patients who achieved MRD negativity, using a minimum sensitivity threshold of 1 in 10 5 nucleated cells or higher, in accordance with IMWG criteria.

Multiparameter flow cytometric remission is zestril 2 5 mg most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation. Nitya Nathwani, Nitya Nathwani. Rebecca Silbermann, Rebecca Silbermann. Additional secondary end points, including complete definitions, are provided in the supplemental Appendix. All patients received four day induction cycles and two day consolidation cycles of oral lenalidomide 25 mg daily on days, subcutaneous bortezomib 1.

Hematopoietic reconstitution was comparable for both groups; the median number of days for neutrophil and platelet engraftment were 12 and 13 for the D-RVd group, and 12 and 12 for the RVd group, respectively. In the D-RVd group, fewer patients discontinued during induction 1. Daratumumab plus bortezomib, melphalan, and prednisone for untreated myeloma.

Additional studies of D-RVd as therapy for patients with high-risk NDMM are needed to better understand its potential impact in these patients. Prognostic value of deep sequencing method for minimal residual disease detection in multiple myeloma. Carla de Boer, Carla de Boer. A lower percentage of patients underwent transplant in the RVd arm It is worth noting that this imbalance was due to a higher rate of treatment discontinuation in the RVd group compared with the D-RVd group.

Nearly one-half of all patients The intent-to-treat population was defined as all randomized patients. Adding daratumumab to RVd did not lead to unexpected safety concerns. Costa, Caitlin Costello, Andrew J. Cowan, Binod Dhakal, Yvonne A. Holstein, Andrzej Jakubowiak, Jonathan L. Orlowski, Brandi Reeves, Paul G.

Richardson, Cesar Rodriguez, Douglas W. Sborov, Nina Shah, Kenneth H. Voorhees, Andrew Whiteley, Tanya M. Wildes, and Jeffrey Zonder.

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A cheap and widely available drug can help save the lives of patients seriously ill with coronavirus. The low-dose steroid treatment dexamethasone is a major breakthrough in the fight against the deadly virus, UK experts say. The drug is part of the world's biggest trial testing existing treatments to see if they also work for coronavirus. It cut the risk of death by a third for patients on ventilators.

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