Celebrex 200 mg

Celecoxib is a medicine used to treat pain or inflammation caused by many conditions, including arthritis, ankylosing spondylitis, migraines, and menstrual pain. This medicine is used in kids with juvenile rheumatoid arthritis who are 2 years old or older. Celecoxib works by preventing the body from producing a substance that causes pain and inflammation. Celecoxib can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use this medicine just before or after heart bypass surgery coronary artery bypass graft, or CABG.

Aspirin allergy, chronic hepatitis, perioperative pain resulting from coronary artery bypass graft surgery. Risk of GI bleeding, ulceration, and perforation; factors that increase risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs such as aspirin, anticoagulants; or selective serotonin reuptake inhibitors SSRIs ; smoking; use of alcohol; older age; and poor general health status. Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include elderly individuals; those with impaired renal function, hypovolemia, heart failure, liver dysfunction, or salt depletion, and those taking diuretics, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers. NSAIDs may cause serious skin reacitons including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, may occur without warning or without prior known sulfa allergy; discontinue at first sign of rash.

Doctors prescribe Celebrex to treat pain, swelling, and stiffness of arthritis and some other conditions. NSAIDs block swelling, pain, and fever. Celebrex works by stopping the production of COX-2, a natural substance in the body that causes pain and inflammation. Also, a study in the May issue of the journal Human Psychopharmacology suggested that celecoxib holds promise as an add-on treatment for people with depression. Celebrex 200 mg researchers noted, though, that more study needs to be done to determine its safety and effectiveness long-term.

Salt Composition: Celecoxib. Origin of Medicine: United States of America. Celebrex mg capsule contains the active ingredient Celecoxib. It is used in adults for the relief of signs and symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

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How does it work mechanism of action? Celecoxib is a nonsteroidal anti-inflammatory drug NSAID, for example, ibuprofen Motrin, aspirin, and naproxen Naprosyn used to treat arthritis, pain, menstrual cramps, and colonic polyps. Prostaglandins are chemicals that are important contributors to the inflammation of arthritis that causes pain, fever, swelling and tenderness. Celecoxib blocks the enzyme that makes prostaglandins cyclooxygenase 2, resulting in lower concentrations of prostaglandins. As a consequence, inflammation and its accompanying pain, fever, swelling and tenderness are reduced.

Celebrex mg Capsule 10s strip may decrease the effectiveness of some antihypertensive medications when given together. This may lead to uncontrolled blood pressure due to failure of antihypertensive therapy. These hormones can cause heavy periods and period pain. Thus, reduction in prostaglandins will help to ease period pain and at the same time reduce heavy bleeding from periods, but Celebrex mg Capsule 10s strip does not reduce the number of days the period lasts. It is not advisable to use Celebrex mg Capsule 10s strip if you are on a blood thinning agent, as this will increase the risk of bleeding.

Distributor: Zuellig Pharma. Each mg capsule contains mg celecoxib. Capsule shells contain gelatin, titanium dioxide, and ink gold SB mg capsule or ink green SB mg capsule. Pharmacology: Pharmacodynamics: The mechanism of action of celecoxib is via inhibition of prostaglandin synthesis primarily by inhibition of cyclooxygenase 2 COX At therapeutic concentrations in humans, celecoxib does not inhibit cyclooxygenase 1 COX

Compared with traditional nonsteroidal anti-inflammatory drugs NSAIDs, celecoxib is no better at improving pain or physical function in patients with RA. RA is a common type of inflammatory arthritis. Participants in the intervention arms received celecoxib in a dosage of or mg per day. Short-term serious adverse events, such as headache, dyspepsia, diarrhea, and abdominal pain, and total withdrawals or discontinuation rates were evaluated; there was no difference in the rates of short-term serious adverse events between celecoxib and placebo.

Pharmacodynamic properties Celecoxib is a specific cyclooxygenase-2 inhibitor SCI. Cyclooxygenase-2 COX-2 is induced in response to inflammatory stimuli. This leads to the synthesis and accumulation of inflammatory prostanoids, in particular prostaglandin E2, causing inflammation, oedema and pain. Celecoxib acts as an anti-inflammatory, analgesic and anti-pyretic agent by blocking the production of inflammatory prostanoids via COX-2 inhibition.

Cardiovascular disease or cardiovascular risk factors: Treatment with CELEBREX, celebrex 200 mg at doses higher than mg per day, should not be used in patients with pre-existing cardiovascular disease congestive heart failure NYHA II-IV, ischemic heart disease, cerebrovascular disease, or patients with risk factors for cardiovascular disease e. Patients may be instructed to take an additional dose of mg on any given day, if needed. Dosage And Administration Dosing Considerations Cardiovascular disease or cardiovascular risk factors: Treatment with CELEBREX, particularly at doses higher than mg per day, should not be used in patients with pre-existing cardiovascular disease congestive heart failure NYHA II-IV, ischemic heart disease, cerebrovascular disease, or patients with risk factors for cardiovascular disease e. Other Resources Visit Originals.

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The Ministry of Public Health. International Health Regulations. Epidemiological Surveillance. National Tuberculosis Program. No Tobacco Control Program.

Government of Newfoundland and Labrador. Strength This refers to the amount of the active medicinal ingredient e. Celebrex 200 mg Status Open - Drugs which are reimbursed with no criteria or prior approval. Note: a drug may have limitations that restrict usage.

You've come to the right place! Celecoxib is used to treat different types of pain such as pain from osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and painful periods. In New Zealand celecoxib is available as capsules mg and mg. For most people taking celecoxib is safe but extra care is needed in some situations, for example if It can also be harmful to take celecoxib when you are dehydrated or have been sick with diarrhoea runny poos or vomiting being sick.

Active gastro-intestinal bleeding; active gastro-intestinal ulceration; cerebrovascular disease; inflammatory bowel disease; ischaemic heart disease; mild to severe heart failure; peripheral arterial disease. Allergic disorders; cardiac impairment NSAIDs may impair renal function ; coagulation defects; connective-tissue disorders; dehydration risk of renal impairment ; elderly risk of serious side-effects and fatalities ; history of cardiac failure; history of gastro-intestinal disorders; hypertension; left ventricular dysfunction; may mask symptoms of infection; oedema; risk factors for cardiovascular events. Anaemia; anxiety; arrhythmias; breast tenderness; burping; cerebral infarction; chest pain; conjunctivitis; constipation; depression; drowsiness; dysphonia; electrolyte imbalance; embolism and thrombosis; fatigue; haemorrhage; hearing impairment; heart failure; hepatic disorders; lipoma; lower limb fracture; muscle complaints; nocturia; oral disorders; palpitations; paraesthesia; respiratory disorders; tinnitus; vision blurred; vitreous floater. Acute kidney injury more common in patients with pre-existing renal impairment ; alopecia; angioedema; anosmia; ataxia; confusion; flushing; hallucination; intracranial haemorrhage; leucopenia; meningitis aseptic; menstrual disorder; myositis; nephritis tubulointerstitial; nephropathy; pancreatitis; pancytopenia; photosensitivity reaction; seizures; severe cutaneous adverse reactions SCARs ; taste altered; thrombocytopenia; vasculitis.

Indications: CELEBREX is indicated for the management of the celebrex 200 mg and symptoms of osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis in patients 2 years and older, and ankylosing spondylitis; for the management of acute pain in adults, and for the management of primary dysmenorrhea. Primary end point: ulcer complication, defined as perforation, gastric outlet obstruction, and bleeding. Twenty-two percent of patients were taking low-dose aspirin for CV prophylaxis. Additionally, there was a 4-month sub-study assessing the effects of the 3 drugs on blood pressure as measured by ambulatory monitoring. CV adverse events were adjudicated by an independent cardiovascular safety committee commissioned by the study's Data Safety Monitoring Board.