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Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating. Duloxetine was approved for medical use in the United States in Duloxetine is recommended as a first-line agent for the treatment of chemotherapy-induced neuropathy by the American Society of Clinical Oncology, as a first-line therapy for fibromyalgia in the presence of mood disorders by the German Interdisciplinary Association for Pain Therapy, as a Grade B recommendation for the treatment of diabetic neuropathy by the American Association for Neurology and as a level A recommendation in certain neuropathic states by the European Federation of Neurological Societies. Food and Drug Administration approved duloxetine to treat chronic musculoskeletal pain, including discomfort from osteoarthritis and chronic lower back pain. In 4 clinical trials of duloxetine for the treatment of MDD, sexual dysfunction occurred significantly more frequently in patients treated with duloxetine than those treated with placebo, and this difference occurred only in men.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide. Duloxetine is used to treat major depressive disorder in adults. Duloxetine is also used to treat general anxiety disorder in adults and children at least 7 years old. Some brands of duloxetine are also used to treat fibromyalgia a chronic pain disorder.

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Duloxetine, sold under the brand name Cymbalta among others, 1 is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. Duloxetine is a serotonin—norepinephrine reuptake inhibitor SNRI. Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating. Duloxetine was approved for medical use in the United States and in the European Union in The main uses of duloxetine are in major depressive disorder, generalized anxiety disorder, neuropathic pain, chronic musculoskeletal pain, and fibromyalgia. Duloxetine is recommended as a first-line agent for the treatment of chemotherapy-induced neuropathy by the American Society of Clinical Oncology, 13 as a first-line therapy for fibromyalgia in the presence of mood disorders by the German Interdisciplinary Association for Pain Therapy, 14 as a Grade B recommendation for the treatment of diabetic neuropathy by the American Association for Neurology 15 and as a level A recommendation in certain neuropathic states by the European Federation of Neurological Societies. Duloxetine was approved for the treatment of major depression in

Duloxetine Cymbalta is a serotonin and norepinephrine reuptake inhibitor in the same class as venlafaxine Effexor. Food and Drug Administration FDA for use in the treatment of major depressive disorder and of diabetic peripheral neuropathic pain. In Europe it is marketed for the treatment of stress urinary incontinence; it is not approved for that indication in the United Cymbalta 15 mg. Duloxetine is considered to be safe. In one open-label study 1 there were seven suicide attempts among 1, patients in one year one suicide attempt per patient-years of drug exposure and no cases of fatal acute overdose. Duloxetine should not be used in patients taking a monoamine oxidase inhibitor MAOI, including a period of five days before initiation of the MAOI and 14 days after its discontinuation.

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Do not take duloxetine within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Duloxetine is also used to treat fibromyalgia a chronic pain disorder in adults and children at least 13 years old. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Your doctor should check your progress at regular visits.

White to almost white pellets in a hard gelatine capsule size 4. The capsule body and cap are light blue. The recommended dose of Duloxetine is 40 mg twice daily without regard to meals. After weeks of treatment, patients should be re-assessed in order to evaluate the benefit and tolerability of the therapy. Some patients may benefit from starting treatment at a dose of 20 mg twice daily for two weeks before increasing to the recommended dose of 40 mg twice daily. Dose escalation may decrease, though not eliminate, the risk of nausea and dizziness.

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Duloxetine is the first serotonin norepinephrine reuptake inhibitor SNRI to be approved for the treatment of fibromyalgia. Duloxetine was originally approved in for major depressive disorder. In addition to approval for the management of fibromyalgia, duloxetine is also approved for major depressive disorder, generalized anxiety disorder, and diabetic peripheral neuropathy. The recommended dose for fibromyalgia cymbalta 15 mg 60 mg once daily. Treatment should be initiated at 30 mg daily for one week before escalating to 60 mg daily. Duloxetine appears to be effective in fibromyalgia with or without major depressive disorder.

Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening, and for emergence of suicidal thoughts and behaviors. Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water. The 20 and 60 mg capsules also contain iron oxide yellow. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time. For some patients, it may be desirable to start at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily.