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Zofran is a medication used in the prevention of nausea and vomiting in a variety of clinical settings. Zofran medication is used for preventing nausea and vomiting in certain instances, including postoperatively and during some instances of chemotherapy and radiotherapy in cancer patients. Zofran medication belongs to a class of medications known as 5-HT 3 receptor antagonists. Found centrally and peripherally in the nervous system, these receptors may be affected by Zofran tablets in both areas and produce a relief from symptoms of emesis. After oral administration, the active ingredients in Zofran generally demonstrate a half-life of under 7 hours. The majority of Zofran's active ingredients are bound to proteins in the plasma and the drug is largely eliminated as conjugated metabolites in the urine.
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Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery.
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