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Acute coronary syndromes ACS remain life-threatening disorders that are associated with high morbidity and mortality. However, there is substantial inter-individual variability in response to clopidogrel treatment in addition to prolonged recovery of platelet reactivity as a result of irreversible binding to P2Y 12 receptors. While FDA has issued a boxed warning for CYP2C19 poor metabolizers due to a potentially reduced efficacy in these patients, results from multivariate analyses suggest that additional factors, including age, sex, obesity, concurrent diseases and drug-drug interactions, may all contribute to the overall between-subject variability in treatment response. Cardiovascular disease CVD is currently the leading cause of death worldwide. As a consequence, safe and effective antiplatelet therapy is essential for reducing the high morbidity and mortality of this disease. Although clopidogrel is safe and effective in many patients, there is substantial variability in treatment response between individuals.
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Applies to clopidogrel: oral tablet. Tests are available to identify patients who are CYP2C19 poor metabolizers. Along with its needed effects, clopidogrel the active ingredient contained in Plavix may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects of clopidogrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
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