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Whitehouse Station, NJ - Merck's blockbuster cholesterol-lowering agent, Zocor simvastatin, loses its US patent protection tomorrow, when the first generic competitors will appear.
Under the deal, members of UnitedHealth Group Inc. Both Merck and UnitedHealth say the arrangement demonstrates how market competition drives down costs, benefiting patients. Teva Pharmaceutical Industries Ltd. That is what some consumer advocates fear. Sure there are short-term consumer benefits, but what about the long term?
We compared atorvastatin with simvastatin-based therapies in a prospective observational study of patients with severe hyperlipidaemia. Atorvastatin 10 mg therapy was substituted for simvastatin 20 mg, 20 mg for 40 mg, 40 mg for simvastatin 40 mg plus resin, and 80 mg for simvastatin-fibrate-resin therapy. Lipid and safety profiles were assessed. These data suggest that atorvastatin is more effective than current simvastatin-based therapies in achieving treatment targets in patients with familial hypercholesterolaemia but at the expense of a possible increase in side-effects. This issue needs further study in randomized controlled trials.
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A bidding war may soon be under way with Merck's pricing strategy for its off-patent blockbuster cholesterol drug Zocor simvastatin. The move may cause generics manufacturers to cut their prices even further to keep a presence in the market.
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These drugs also modestly raise levels of good cholesterol HDL or high-density lipoprotein. A large number of drugs interact with both atorvastatin and simvastatin, so be sure to tell your doctor about all your other medications if they prescribe you either of these cholesterol drugs.
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