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Common side effects include diarrhea, constipation, headache, sleepiness, and itchiness. Ondansetron was patented in and approved for medical use in The 5-HT 3 receptor antagonists are the primary medications used to treat and prevent chemotherapy-induced nausea and vomiting and radiotherapy-induced nausea and vomiting. A number of medications including ondansetron appear to be effective in controlling postoperative nausea and vomiting. It is more effective than metoclopramide, and less sedating than cyclizine or droperidol. Ondansetron is used off-label to treat morning sickness and hyperemesis gravidarum of pregnancy.
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But I was way off in the weight loss and nausea department because I was lucky enough to be diagnosed with breast cancer in, 20 years after the introduction of the highly effective anti-nausea drug Zofran. Before the introduction of this and other powerful antiemetics, going through chemo was incredibly rough. I realize nausea and vomiting is a weird thing to uh bring up. I was certainly clueless about this; ditto for many others who told me they feared the worst, thanks to Hollywood. A longtime oncologist, public health researcher and national thought leader in patient care, Lyman said he remembers only too well what it was like treating cancer patients before effective anti-nausea meds came on the scene. The last two chemo treatments were a night-and-day difference.
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