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The researchers say that the drug has ''disappointingly little overall benefit'' and is not cost-effective, and that better treatments are needed. Even the drugs' staunchest advocates say that they offer modest benefits at best, affording perhaps a short delay in a patient's decline. But when small changes in functioning occur, it may be hard to tell whether they are owing to the drug or to the ups and downs of the disease itself. Although the patients taking the drug did have slightly higher scores on mental tests, after three years they did not differ from the placebo group in their rates of being put in a nursing home or becoming disabled.

In England and Wales, among people aged aricept uk price years, the incidence is estimated to be 7. They are acetylcholinesterase inhibitors AChEIs. It is a voltage-dependent, moderate-affinity, uncompetitive N -methyl-d-aspartate receptor antagonist. The search strategy can be found in Appendix 2. Bibliographies of included studies were searched for further relevant studies.

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