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Linezolid and tedizolid demonstrate activity in vitro against several Mycobacterium spp, including both Mycobacterium tuberculosis and nontuberculous mycobacterium. In addition, linezolid and tedizolid are active in vitro against numerous Nocardia spp. Linezolid abolishes toxin production and reduces sporulation in Bacillus anthracis in vitro; therefore, it is a treatment option for select infections due to anthrax 19,20. Linezolid is approved by the US Food and Drug Administration FDA for treatment of adults and children with pneumonia nosocomial and community-acquired and skin and skin structure infections complicated and uncomplicated, including those due to MRSA and VRE 21,22.

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