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REMINYL prolonged release capsules contain galantamine hydrobromide, equivalent to respectively 8, 16 and 24 mg galantamine base. Galantamine doses of 16 and 24 mg daily maintained the NPI score throughout the observation period whereas the score of the placebo patients clearly deteriorated, as a result of the emergence of behavioral disturbances. About half of the deaths in both placebo and active treatment groups were due to vascular causes. This pattern was consistently observed in all analyses of the data. After repeated oral dosing of 12 mg galantamine b. The pharmacokinetics of galantamine are linear in the dose range mg b.

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Conduction disorders eg, bradycardia, AV block. Bladder outflow obstruction. Monitor for active or occult GI bleed, respiratory or neurological effects, and patient's weight. Maintain adequate hydration. Potentiates neuromuscular blockers eg, succinylcholine, cholinesterase inhibitors, cholinergic agonists eg, bethanechol.

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Galantamine hydrobromide is a white to almost white powder and is sparingly soluble in water. Inactive ingredients include diethyl phthalate, ethylcellulose, gelatin, hypromellose, polyethylene glycol, sugar spheres sucrose and starch, and titanium dioxide. The 16 mg capsule also contains red ferric oxide. The 24 mg capsule also contains red ferric oxide and yellow ferric oxide. Inactive ingredients include colloidal silicon dioxide, crospovidone, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, propylene glycol, talc, and titanium dioxide. The 4 mg tablets contain yellow ferric oxide.

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