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Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
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The prolonged QT interval is both widely seen and associated with the potentially deadly rhythm, Torsades de Pointes TdP. Some of these drugs have either been restricted or withdrawn from the market due to the increased incidence of fatal polymorphic ventricular tachycardia.
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This means that the interval required for re-excitation is prolonged and arrhythmias are suppressed. Amiodarone is effective in both atrial and ventricular arrhythmias.
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Nutritional rickets results from inadequate exposure to sunlight or deficiency of vitamin D. Metabolic rickets and osteomalacia result from abnormality in synthesis of or response to calcitriol, the active form of vitamin D. Treatment of osteomalacia and rickets is by vitamin D supplements. Some drugs, for example anticonvulsants phenytoin, phenobarbital and corticosteroids can lead to osteomalacia and rickets by depressing vitamin D dependent calcium uptake in the intestine.
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Authored by Dr. Gregory Obara, MD