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Galantamine is prescribed for people who have dementia which is associated with Alzheimer's disease. This is a chemical which allows nerve cells in the brain to communicate with each other, and it is known that people with dementia have low levels of it.
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Galantamine 4, a naturally occurring plant tertiary alkaloid, is a reversible AChE inhibitor that is a weak positive allosteric modular of nAChRs. The proposed presynaptic actions of galantamine may also lead to the modulation of glutamate, serotonin, and norepinephrine release, all of which are affected in AD. Unlike rivastigmine, galantamine is metabolized by cytochrome P enzymes, CYP2D6 and CYP3A4, with doses of this drug being lowered if it is co-administered with other drugs that inhibit these enzymes. It is a reversible competitive inhibitor of acetylcholinesterase. Uses Galantamine has been used for many years to treat a range of neurological diseases, but is currently used in the treatment of various provera 2.5 mg.
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