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Cetirizine is an antihistamine medicine that helps the symptoms of allergies.
Like other phenothiazines, it exerts an antiemetic effect through a depressant action on the chemoreceptor trigger zone.
Analyses of 17 placebo-controlled trials modal duration of 10 weeks, largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients between 1. Over the course of a typical week controlled trial, the rate of death in drug-treated patients was approximately 4. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular eg, heart failure, sudden death or infectious eg, pneumonia in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic s of the patients is not clear. Chemotherapy-induced nausea and vomiting off-label use IV, Oral: 5 to 10 mg once prior to chemotherapy Ref.
Prochlorperazine is used for the treatment of acute migraine, A but is not licensed for this indication. An ECG may be required, particularly if physical examination identifies cardiovascular risk factors, personal history of cardiovascular disease, or if the patient is being admitted as an inpatient. See also Prescribing in the elderly. Elderly in adults ; hypotension more likely after intramuscular injection ; susceptibility to QT interval prolongation. Agranulocytosis; confusion; embolism and thrombosis; neuroleptic malignant syndrome discontinue—potentially fatal. Phenothiazines cause less depression of consciousness and respiration than other sedatives.
Sometimes used for dogs and cats to reduce nausea and vomiting. The exact mechanism of action of the phenothiazine derivatives is not completely understood. The drugs work by somehow blocking dopamine receptors in the nervous system and may even inhibit the release of dopamine. These drugs are thought to affect the part of the brain responsible for controlling body temperature, metabolic rate, vomiting, blood pressure and alertness. Compared to other phenothiazines, prochlorperazine has mild sedative effects and strong anti-vomiting effects. Precautions and Side Effects While generally safe and effective when prescribed by a veterinarian, prochlorperazine can cause side effects in some animals.
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IM: mg administered hours before induction of anesthesia; may be repeated once 30 minutes after initial dose. Lower initial dose and adjust gradually; 2. Restlessness immediate restlessness or agitation may be treated with diphenhydramine 25 mg IV push. Coma, severe CNS depression, concurrent use of large amounts of CNS depressants, poorly controlled seizure disorder, subcortical brain damage. Risk of extrapyramidal symptoms, neuroleptic malignant syndrome, hypotension may be particularly severe in patients with pheochromocytoma or mitral insufficiency.
Opioid analgesics are useful compazine suppositories 25 mg for treating pain of various etiologies; however, adverse effects are potential limitations to their use. Strategies to minimize adverse effects of opioids include dose reduction, symptomatic management, opioid rotation, and changing the route of administration. Nausea occurs in approximately 25 percent of patients; prophylactic measures may not be required. Patients who do develop nausea will require antiemetic treatment with an anti-psychotic, prokinetic agent, or serotonin antagonist. Understanding the mechanism for opioid-induced nausea will aid in the selection of appropriate agents. Constipation is considered an expected side effect with chronic opioid use.
Intramuscular Nausea and vomiting Adult: As prochlorperazine mesilate: As prochlorperazine edisylate: Initially. Elderly: Dose reduction may be necessary. Adult: As prochlorperazine mesilate: As prochlorperazine edisylate: Initially, mg via deep inj, may repeat dose hourly, if necessary.
How Prochlorperazine works Prochlorperazine is a dopamine antagonist. Dopamine controls the region in the brain that causes nausea and vomiting and this medicine blocks the action of dopamine.
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Discontinue 48 hrs before to 24 hrs after myelography. Monitor blood, liver, and ocular function. Children with acute illness or dehydration. Pregnancy, nursing mothers: not recommended. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity.
Prochlorperazine is recommended for medication rebound or overuse headaches, intractable headaches, status migrainosus, and for headaches and migraines in which severe nausea and vomiting are the predominant symptoms. It is also considered among the most effective medications for severe childhood migraines, with and compazine suppository 25 mg nausea. Compazine is not an opioid, and it is not addictive. The anti-headache and anti-migraine mechanisms of Compazine are not well understood, but the drug's effectiveness seems to be tied to its influence on dopamine—a neurotransmitter that acts on the brain to modulate muscle movement, emotions, and pain and the body affecting gastrointestinal activity and muscle movement. Researchers suggest that people who have migraines may be hypersensitive to dopamine. What's best for you will be determined by your doctor based on the severity of your symptoms, your ability to keep things down, and more.