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Besides the potent anti-inflammatory corticosteroid dexamethasone, these include the anti-malaria medication hydroxychloroquine, the antibiotic azithromycin, the anti-HIV drug cocktail lopinavir—ritonavir, the anti-inflammatory antibody tocilizumab, and convalescent plasma from cured patients. Not only because dexamethasone is the first and thus far only drug to significantly improve survival in a RCT in COVID patients, but also because it is a very well-known and extensively used drug, which is widely available and very cheap 4. While the main focus of initial RCT against COVID has been on antiviral drugs, such as remdesivir, it has become clear that a significant number of severe cases and fatalities are due to an overreaction of the immune system, leading to hyperinflammation and to macrophage activation syndrome MAS.

First, we tried the antimalarial drug hydroxychloroquine. Then we tested the antiviral drug remdesivir. This time it's an old anti-inflammatory drug, dexamethasone, which has been described as cheap, old and boring. Preliminary results from a clinical trial just released indicate the drug seems to reduce your chance of dying from COVID if you're in hospital and need oxygen or a machine to help you breathe.

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Nial is also a director of the medicinal cannabis company Canngea Pty Ltd and a Standards Australia committee member for sunscreen agents. These include severe allergies, some types of nausea and vomiting, arthritis, swelling of the brain and spinal cord, severe asthma, and for breathing difficulties in newborn babies. Patients in each of those groups were given dexamethasone 6mg once a day, either as a tablet or via intravenous injection, for ten days. Here's where the science is up to.

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Furthermore, the most appropriate corticosteroid and dose in the treatment of COVID have remained uncertain. We conducted a study to assess the effectiveness of methylprednisolone treatment versus dexamethasone for hospitalized COVID patients. Data were assessed based on a 9-point WHO ordinal scale extending from uninfected point 0 to death point 8. There were no significant differences between the groups on admission. However, the intervention group demonstrated significantly better clinical status compared to the control group at day 5 4.

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