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Treatment with levodopa is associated with impulse control disorders, including pathological gambling, binge eating, and hypersexuality. Cushing's syndrome; diabetes mellitus; endocrine disorders; history of convulsions; history of myocardial infarction with residual arrhythmia; history of peptic ulcer; hyperthyroidism; osteomalacia; phaeochromocytoma; psychiatric illness avoid if severe and discontinue if deterioration ; severe cardiovascular disease; severe pulmonary disease; susceptibility to angle-closure glaucoma. Management of excessive daytime sleepiness should focus on the identification of an underlying cause, such as depression or concomitant medication. Patients should be counselled on improving sleep behaviour. A lower dose may not achieve full inhibition of extracerebral dopa-decarboxylase, with a resultant increase in side-effects. Adult Initially — mg twice daily, dose to be given at least 6 hours apart; dose adjusted according to response at intervals of at least 2 days. Adult consult product literature.

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The score line is not intended for breaking the tablet. The tablet can be divided into equal doses. Patients receiving less than this amount of carbidopa are more likely to experience nausea and vomiting. Standard antiparkinsonian drugs, other than levodopa alone, may be continued while 'Sinemet' is being administered, although their dosage may have to be adjusted. Because both therapeutic and adverse effects are seen more rapidly with 'Sinemet' than with levodopa, patients should be carefully monitored during the dosage adjustment period. Involuntary movements, particularly blepharospasm, are a useful early sign of excess dosage in some patients. Titration upward may be required in some patients to achieve optimum dosage of carbidopa.

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Due to ongoing issues with fuel supply in the UK, there have been concerns about potential delays in the delivery of drug supplies to pharmacies across all 4 nations. However, the Royal Pharmaceutical Society has made assurances that deliveries of essential medication are continuing as usual to pharmacies. If you're taking medication for your Parkinson's, we recommend waiting until you have used up your existing supply before getting a new one. If you are having any difficulty with renewing your medication, please get in touch with our helpline, who will be able to advise you further, on Below are the types of levodopa drugs.

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