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Question Can modulators of cerebrovascular endothelial function, including isosorbide mononitrate ISMN; a nitric oxide donor and cilostazol a phosphodiesterase-3 inhibitor, improve long-term outcomes after lacunar ischemic stroke? Importance Cerebral small vessel disease cSVD is a common cause of stroke lacunar stroke, is the most common cause of vascular cognitive impairment, and impairs mobility and mood but has no specific treatment. Objective To test the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate ISMN and cilostazol treatment on vascular, functional, and cognitive outcomes in patients with lacunar stroke.
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Authored by Richard Gayles, MD
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