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The present invention relates to medicine, particularly Nimodipine solid dispersant, tablet and preparation method thereof. Nimodipine raw material is light yellow crystalline powder, odorless, tasteless, almost insoluble in water, in Biopharmaceutics Classification system, belong to dissolubility low, the Equations of The Second Kind medicine that permeability is high, dissolution is the rate-limiting step of its bioavailability, for this kind of medicine, improving dissolution is the effective ways improving its bioavailability. Solid dispersions technique is a kind of effective ways improving insoluble medicine bioavailability, exists, have higher dissolution and bioavailability at solid dispersion Chinese medicine with amorphous state. Existing solid dispersion preparation method can be extrusion by melting. But the defect of extrusion by melting is: the solid dispersion particle diameter of preparation is uneven, after must pass through pulverizing, granulation, just tabletting can be carried out.
This application claims the benefit of U. In some embodiments, the non-aqueous liquid compositions disclosed herein do not exhibit substantial degradation under t conditions e. In a particular embodiment, non-aqueous liquid compositions disclosed herein do not exhibit substantial degradation under t conditions e. In one embodiment, the shelf life of the non-aqueous liquid when it is contained in a suitable container container exhibits a shelf life under t conditions of at least 6 month, more preferably at least 12 months, still more preferably at least 15 months, yet more preferably at least 18 months, most preferably at least 21 months and in particular at least 24 months. Inject the Nimodipine Working Standard. A SumoBrain Solutions Company. Search Expert Search Quick Search. Non-Aqueous Liquid Nimodipine Compositions. Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. A non-aqueous liquid composition consisting essentially of nimodipine, from about 0.
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Each film-coated tablet contains 30mg nimotop 40 mg. Each sterile solution contains 10 mg nimodipine in 50 ml vials of aqueous alcoholic solvent 0. Pharmacology: Pharmacodynamics: Nimodipine has a predilective cerebral anti-vasoconstrictive and anti-ischaemic activity. Vasoconstrictions provoked in vitro by various vasoactive substances e. Nimodipine also has neuropharmacological and psychopharmacological properties.
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The recommended dose of Nimodipine is two tablets of 30 mg nimodipine 60 mg at 4-hourly intervals total daily dose mg to be taken with water. Swallow the tablets whole with a little liquid, with or without food. Avoid taking grapefruit juice. Prophylactic administration should commence within 4-days of onset of subarachnoid haemorrhage and should be continued for 21 days. In an event of surgical intervention, administration of tablets should be continued to complete the days treatment period. In patients who develop adverse reactions the dose of Nimodipine should be decreased as necessary or the treatment discontinued.
Delayed cerebral ischemia DCI is a major factor contributing to the inferior outcome of patients with spontaneous subarachnoid hemorrhage SAH. Nimodipine and induced hypertension using vasopressors are an integral part of standard therapy. Demographic and clinical data such as age, sex, World Federation of Neurosurgical Societies WFNS grade, BMI, Fisher grade, history of arterial hypertension and smoking, aneurysm location, C-reactive protein CRP level, and detailed dosage of vasopressors and nimodipine during the treatment period were evaluated. Clinical outcome was analyzed using the modified Rankin Scale mRS 6 months after treatment. Additionally, mean arterial pressure MAP, age, nimodipine, and vasopressor dose cutoff were evaluated with regard to outcome. Hence, it seems encouraging that a maximum nimodipine dosage can be achieved despite the need for a higher vasopressor dose in patients with SAH.